Validated, Stability-Indicated Quantitative Purity Test for Triethylenetetramine Tetrachlorhydrate by Automated Multiple Development
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چکیده
منابع مشابه
Validated, stability-indicated quantitative purity test for triethylenetetramine tetrachlorhydrate by automated multiple development.
There is a monography of Triethylenetetramine dichlorhydrate (Trientine) in the United States Pharmacopeia. But neither the base nor the salts di- or tetra-chlorhydrate are in the European Pharmacopeia. Triethylène tetramine tetrachlorhydrate, used by AGEPS now as matural, is more soluble then triethylene tetramine dichlorhydrate. It is administred to patients with Wilson's disease, which resul...
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The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson's disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the physical stability has been studied by differential scanning calorimetry, high-pressure thermal analysis, dynamic vapor sorption, and X-ray diffraction as a function of temperature. In addi...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2007
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/45.6.315